industrial hygiene pharmaceuticals

New ACGIH STEL for Peracetic Acid The American Conference of Governmental Industrial Hygienists (ACGIH) Board of Directors has approved the 2014 occupational exposure limits. Included in these limits is a new short-term exposure limit (STEL) for peracetic acid (PAA, C.A.S 79-21-0). This new STEL is 0.4 ppm over a rolling 15-minute period. Peracetic acid is a strong oxidant and is often contained in disinfectants that are used in the biotechnology,


Our catalog of occupational exposure limit monographs for pharmaceuticals continues to grow Affygility Solutions is pleased to announce that is has added eight additional active pharmaceutical ingredients (APIs) to its growing catalog of OEL Fastrac monographs. APIs that have been added in the last week include: Colchicine; Dutasteride; Esomeprazole; Fluphenazine; Indomemethacin; Liothyronine Sodium; Oxycodone; and Ranolazine. Each OEL Fastrac monograph contains important information necessary for the successful execution of your


Here at Affygility Solutions, we often get asked the question, “Does the form of the compound change its control band assignment?” In this short 2:37 minute video, Dean M. Calhoun, CIH, President and CEO of Affygility Solutions answers that question. If you have any questions, comments, or need additional information on the risk management of potent compounds, please contact Affygility Solutions via their main website.


Here at Affygility Solutions, we are often asked the question, “Should I use 4 or 5 controls bands in my occupational exposure control banding system? In this brief video, Dean M. Calhoun, CIH, the President and CEO of Affygility Solutions answers this important question. In the image below, we present a comparison between the Affygility Solutions control banding system, the Merck system, and a typical 4-band system. When translating from


When evaluating an occupational health hazard, don’t forget mixture calculations.  Here at Affygility Solutions we perform a lot of environmental, health and safety (EH&S) audits, and during the industrial hygiene portion of the EH&S audit, one of the frequent findings is that the mixture calculations for airborne contaminants is overlooked.  In addition to being a possible Occupational Safety and Health Administration (OSHA) regulatory compliance issue (29 CFR 1910.1000(d)(2)(i), [pullquote]if those


Phosgene leak at pesticide manufacturer facility kills employee The United States Chemical Safety Board (CSB) released its animation of the phosgene leak that led to a serious accident in January, 2010.  This accident led to a catastrophic phosgene leak which killed an employee. Phosgene is a colorless nonflammable gas that has the odor of freshly cut hay. Phosgene can be used in the manufacture of pharmaceuticals and pesticides. The OSHA Permissible


When establishing occupational exposure limits (OEL) for active pharmaceutical ingredients the equation that is often used is the one that was published in by E.V. Sargent and G.D. Kirk (1988), and presented with slight modification by B.D. Naumann and P.A. Weideman (1995).  This equation is as follows:     Where: OEL = Occupational Exposure Limit NOAEL = No Observable Adverse Effect Level (mg/kg) BW = Body Weight (kg) and typically


Allergic Reactions Common to the Pharmaceutical Industry Pharmaceutical manufacturing facilities and laboratories handle a wide variety of active pharmaceutical ingredients that may produce allergic reactions.  These allergic reactions may include: Allergic Respiratory Reactions; and Skin (or Dermal) Reactions. Allergic Respiratory Reactions Resulting from Exposure to Active Pharmaceutical Ingredients The most common route of occupational exposure to active pharmaceutical ingredients is the respiratory system.  Occupational exposure via the inhalation route may result


Information graphics or infographics are graphical representations of information, data, or knowledge.  These graphics present complex information quickly and clearly.  Below is an infographic on noise and hearing loss. I thought it would be useful sharing with other environmental, health and safety professionals. Pharmaceutical companies that need to comply with OSHA’s hearing conservation standard should have a compliance management software system in place to manage complex regulatory requirements contained in


Environmental, health and safety databases – the top 12 Whether composing a material safety data sheet, evaluating a potent compound, or performing industrial hygiene work; here are the twelve environmental, health and safety toxicology and regulatory databases that all environmental, health and safety professionals should have bookmarked: Toxnet – this is a good place to start.  Toxnet is actually a collection of databases.  Ones that are critical to environmental, health


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