Definition of a Potent Compound

At Affygility Solutions we often get asked, “What is a Potent Compound.” So here’s the definition that we hang our hat on:

“A Potent Compound is defined as a pharmacologically active ingredient or intermediate with biological activity at 150 ug/kg of body weight or below in adults (therapeutic dose at or below 10 milligrams); an active pharmaceutical ingredient or intermediate with an occupational exposure limit (OEL) at or below 10 ug/m^3 of air as an 8-hour time weighted average; a pharmacologically active ingredient or intermediate with high selectivity (i.e. ability to bind to specific receptors or inhibit specific enzymes) and/or the potential to cause cancer, mutations, developmental effects, or reproductive toxicity at low doses (at or near the therapeutic dose or lower); or a novel compound of unknown potency and toxicity.”


About Dean Calhoun

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Dean is the President and CEO of Affygility Solutions. Affygility Solutions provides environmental, health and safety software, potent compound safety, industrial hygiene, containment validation services to the pharmaceutical, biotechnology, and medical device industry. "Dean's Google+ Profile"

Affygility Solutions - provider of potent compound safety, webinars, and compliance management software